Work

Low‐grade glioma: A rare second tumor in retinoblastoma survivors

Year: 2020

Type: article

Abstract: Retinoblastoma survivors with a germline RB1 mutation are at elevated risk for secondary (nonocular) malignancy, but their risk for low-grade glioma (LGG) is unknown. We performed a retrospective review of the Memorial Sloan Kettering Cancer Center and the NCI databases that revealed that three of the 837 5-year survivors of hereditary retinoblastoma were diagnosed with an LGG and a fourth patient (but unilateral and without a germline mutation) was identified at another center. Retinoblastoma survivors may be at increased risk for LGG.

Source: Pediatric Blood & Cancer

DOI: 10.1002/pbc.28770

Authors: Nagma Dalvi, Ruth A. Kleinerman, Sidnei Epelman, David H. Abramson, Ira J. Dunkel

Institutions: Memorial Sloan Kettering Cancer Center, Division of Cancer Epidemiology and Genetics, Hospital Santa Marcelina, Weill Cornell Medicine

Language: English

Topic: Ocular Oncology and Treatments

Subfield: Ophthalmology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Cancer Institute