Work

Commentary on human pluripotent stem cell-based blood–brain barrier models

Year: 2020

Type: editorial

Abstract: In 2012, we provided the first published evidence that human pluripotent stem cells could be differentiated to cells exhibiting markers and phenotypes characteristic of the blood-brain barrier (BBB). In the ensuing years, the initial protocols have been refined, and the research community has identified both positive and negative attributes of this stem cell-based BBB model system. Here, we give our perspective on the current status of these models and their use in the BBB community, as well as highlight key attributes that would benefit from improvement moving forward.

Source: Fluids and Barriers of the CNS

DOI: 10.1186/s12987-020-00222-3

Authors: Ethan S. Lippmann, Samira M. Azarin, Sean P. Palecek, Eric V. Shusta

Institutions: Vanderbilt University, University of Minnesota, University of Wisconsin–Madison

Language: English

Topic: Barrier Structure and Function Studies

Subfield: Neurology

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,680