Year: 2020
Type: article
Abstract: Exosome-driven lipolysis and bone marrow niche remodeling support leukemia expansionSince the bone marrow (BM) microenvironment and adipose tissue provide an attractive sanctuary for cancer progression and the acquisition of drug resistance phenotypes, 1-5 interactions between BM niche components and leukemia have recently attracted interest.However, the mechanisms underlying these complex interactions are not well understood.We previously reported that leukemic cells.through their secreted exosomes, induce microenvironment reprogramming to inhibit normal hematopoiesis and create a self-enforcing microenvironment for their own expansion.6 Here, using syngeneic acute myeloid leukemia (AML)/acute lymphoblastic leukemia (ALL) transplantation and knock-in leukemic mice models, we aimed to understand how leukemia remodels the BM niche.We describe a novel mechanism through which leukemic cells, via their exosomes,
Source: Haematologica
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,157
OpenAlex ID: W3093081877