Work

Outcomes of multiple myeloma patients with del 17p undergoing autologous stem cell transplantation

Year: 2020

Type: article

Abstract: patients who survived or not.Also plasma iron levels did not change between the two groups (Figure 1E), likely because of the low basal levels.On the contrary, hepcidin concentration was significantly increased in males who did not survive (Figure 1F), confirming the predictive role of hepcidin for death in severely affected Covid-19 patients.Assessment of various biomarkers for the ability to predict the outcome of our cohort of Covid-19 points out an important role for hepcidin and iron analyzed at the time of hospital admission.Advanced age, low PaO 2 /FiO 2 ratio, increased CRP and hepcidin and hypoferremia all characterize non-survivors.The role of hepcidin is strengthened by the Kaplan-Meier survival curve and confirmed by the RT analysis, which identified hepcidin as the most important predictor of death among the others recognized predictors.On the other hand, iron levels do not affect survival, likely because of the uniformly low levels in all patients.Interestingly, limiting the analysis to critical patients in ICU, high hepcidin predicts mortality, independently of age, lung function, inflammation and tissue damage.Overall our data suggest that in Covid-19 hepcidin can be considered a marker of morbidity and outcome, of special value for severely compromised patients in ICU.Further studies are necessary to verify whether targeting the hepcidin axis may influence the disease outcome.

Source: American Journal of Hematology

DOI: 10.1002/ajh.26023