Work

Detecting Selection from Linked Sites Using an F -Model

Year: 2020

Type: article

Abstract: ABSTRACT Allele frequencies vary across populations and loci, even in the presence of migration. While most differences may be due to genetic drift, divergent selection will further increase differentiation at some loci. Identifying those is key in studying local adaptation, but remains statistically challenging. A particularly elegant way to describe allele frequency differences among populations connected by migration is the F -model, which measures differences in allele frequencies by population specific F ST coefficients. This model readily accounts for multiple evolutionary forces by partitioning F ST coefficients into locus and population specific components reflecting selection and drift, respectively. Here we present an extension of this model to linked loci by means of a hidden Markov model (HMM) that characterizes the effect of selection on linked markers through correlations in the locus specific component along the genome. Using extensive simulations we show that our method has up to two-fold the statistical power of previous implementations that assume sites to be independent. We finally evidence selection in the human genome by applying our method to data from the Human Genome Diversity Project (HGDP).

Source: Genetics

DOI: 10.1534/genetics.120.303780

Authors: Marco Galimberti, Christoph Leuenberger, Beat Wolf, Sándor Miklós Szilágyi, Matthieu Foll, Daniel Wegmann