Barrett's Esophagus and Esophageal Adenocarcinoma Biomarkers
Year: 2020
Type: article
Abstract: Esophageal adenocarcinoma is a major cause of cancer-related morbidity and mortality in Western countries. The incidences of esophageal adenocarcinoma and its precursor Barrett's esophagus have increased substantially in the last four decades. Current care guidelines recommend that endoscopy be used for the early detection and monitoring of patients with Barrett's esophagus; however, the efficacy of this approach is unclear. To prevent the increasing morbidity and mortality from esophageal adenocarcinoma, there is a tremendous need for early detection and surveillance biomarker assays that are accurate, low-cost, and clinically feasible to implement. The last decade has seen remarkable advances in the development of minimally invasive molecular biomarkers, an effort led in large part by the Early Detection Research Network (EDRN). Advances in multi-omics analysis, the development of swallowable cytology collection devices, and emerging technology have led to promising assays that are likely to be implemented into clinical care in the next decade. In this review, an updated overview of the molecular pathology of Barrett's esophagus and esophageal adenocarcinoma and emerging molecular biomarker assays, as well as the role of EDRN in biomarker discovery and validation, will be discussed.
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: Genetic Determinants of Barrett's Esophagus and Esophageal Adenocarcinoma, A Center for the Convergence of Physical Science and Cancer Biology, (PQC1) Accelerated biological aging and colon polyp to cancer progression, Biomarkers for Reducing Mortality of Cancers of the Colon and Esophagus, Esophageal Cancer from Cells to Population: A Multiscale Approach, San Antonio Center for Biomarkers of Risk for Prostate Cancer (SABOR), Case GI SPORE, The Cleveland Digestive Diseases Research Core Center (DDRCC), Cancer Center Support Grant, Translational Science of Gastrointestinal Cancer Initiation and Progression
OpenAlex ID: W3093551502