Plasma Cathelicidin is Independently Associated with Reduced Lung Function in COPD: Analysis of the Subpopulations and Intermediate Outcome Measures in COPD Study Cohort
Year: 2020
Type: article
Abstract: RATRIONALE: The antimicrobial peptide cathelicidin, also known in humans as LL-37, is a defensin secreted by immune and airway epithelial cells. Deficiencies in this peptide may contribute to adverse pulmonary outcomes in chronic obstructive pulmonary disease (COPD). OBJECTIVES: Using clinical and biological samples from the SubPopulations and InteRmediate Outcome Measures In COPD Study (SPIROMICS), we assessed the associations of plasma cathelicidin levels with cross-sectional and longitudinal COPD outcomes. METHODS: A total of 1609 SPIROMICS participants with COPD and available plasma samples were analyzed. Cathelicidin was modeled dichotomously (lowest quartile [< 50 ng/ml] versus highest 75% [≥ 50 ng/ml]) and continuously per 10 ng/ml. Fixed-effect multilevel regression analyses were used to assess associations between cathelicidin and cross-sectional as well as longitudinal lung function. The associations between cathelicidin and participant-reported retrospective and prospective COPD exacerbations were assessed via logistic regression. MEASUREMENTS AND MAIN RESULTS: < 0.001). No independent associations with longitudinal lung function decline or participant-reported COPD exacerbations were observed. CONCLUSIONS: Reduced cathelicidin is associated with lower lung function at baseline. Plasma cathelicidin may potentially identify COPD patients at increased risk for more severe lung disease.
Authors: Robert M. Burkes, Agathe S. Ceppe, David J. Couper, Alejandro P. Comellas, J. Michael Wells, Stephen P. Peters, Gerard J. Criner, Richard E. Kanner, Robert Paine III, Stephanie A. Christenson, Christopher B. Cooper, Igor Z. Barjaktarevic, Jerry A. Krishnan, Wassim W. Labaki, MeiLan K. Han, Jeffrey L. Curtis, Nadia N. Hansel, Robert A. Wise, M. Bradley Drummond
Institutions: University of North Carolina at Chapel Hill, University of Iowa, University of Iowa Health Care, University of Alabama, University of Alabama at Birmingham, Wake Forest University, Temple University, University of Utah, University of California, San Francisco, University of California, Los Angeles, University of Illinois Chicago, University of Michigan, Michigan Medicine, VA Ann Arbor Healthcare System, Johns Hopkins University
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
Awards: G1235157764, G1568233346, G2099663897, G2212190077, G2847413391, G3027037974, G3868091120, G3999916299, G4749522346, Identifying the Th2 endotype in COPD: clinical and pathologic implications, G7206313631, Clinical Significance of the Antimicrobial Peptide Cathelicidin in Acute Exacerbations of COPD, G8957911378, Environmental Health Sciences Research Center, Mentoring Research in Precision Medicine for Lung Disease
OpenAlex ID: W3093694544