Work

Early-onset colorectal cancer: more than one side to the story

Year: 2020

Type: article

Abstract: Aim: To determine the impact of tumor sidedness on all-cause mortality for early-(age 18-49 years) and older-onset (age ≥50 years) colorectal cancer (CRC).Materials & methods: We conducted a retrospective study of 650,382 patients diagnosed with CRC between 2000 and 2016.We examined the associations of age, tumor sidedness (right colon, left colon and rectum) and all-cause mortality.Results: For early-onset CRC (n = 66,186), mortality was highest in the youngest age group (18-29 years), driven by left-sided colon cancers (vs 50-59 years, hazard ratio: 1.18; 95% CI: 1.03-1.34).5-year risk of death among 18-29year-olds with left-sided colon cancer (0.42, 95% CI: 0.38, 0.46) was higher than all other age groups.Conclusion: Left-sided colon cancers are enriched in younger adults and may be disproportionately fatal.

Source: Colorectal Cancer

DOI: 10.2217/crc-2020-0016

Authors: Nina N Sanford, Pooja Dharwadkar, Caitlin C Murphy

Institutions: Harold C. Simmons Comprehensive Cancer Center, The University of Texas Southwestern Medical Center, University of California, San Francisco, University of California San Francisco Medical Center

Language: English

Topic: Colorectal Cancer Screening and Detection

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

Funder: National Cancer Institute