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Cross-sectional and prospective associations between sleep regularity and metabolic health in the Hispanic Community Health Study/Study of Latinos

Year: 2020
Type: article
Abstract: STUDY OBJECTIVES: Sleep is an emergent, multi-dimensional risk factor for diabetes. Sleep duration, timing, quality, and insomnia have been associated with diabetes risk and glycemic biomarkers, but the role of sleep regularity in the development of metabolic disorders is less clear. METHODS: We analyzed data from 2107 adults, aged 19-64 years, from the Sueño ancillary study of the Hispanic Community Health Study/Study of Latinos, followed over a mean of 5.7 years. Multivariable-adjusted complex survey regression methods were used to model cross-sectional and prospective associations between the sleep regularity index (SRI) in quartiles (Q1-least regular, Q4-most regular) and diabetes (either laboratory-confirmed or self-reported antidiabetic medication use), baseline levels of insulin resistance (HOMA-IR), beta-cell function (HOMA-β), hemoglobin A1c (HbA1c), and their changes over time. RESULTS: Cross-sectionally, lower SRI was associated with higher odds of diabetes (odds ratio [OR]Q1 vs. Q4 = 1.64, 95% CI: 0.98-2.74, ORQ2 vs. Q4 = 1.12, 95% CI: 0.70-1.81, ORQ3 vs. Q4 = 1.00, 95% CI: 0.62-1.62, ptrend = 0.023). The SRI effect was more pronounced in older (aged ≥ 45 years) adults (ORQ1 vs. Q4 = 1.88, 95% CI: 1.14-3.12, pinteraction = 0.060) compared to younger ones. No statistically significant associations were found between SRI and diabetes incidence, as well as baseline HOMA-IR, HOMA-β, and HbA1c values, or their changes over time among adults not taking antidiabetic medication. CONCLUSIONS: Our results suggest that sleep regularity represents another sleep dimension relevant for diabetes risk. Further research is needed to elucidate the relative contribution of sleep regularity to metabolic dysregulation and pathophysiology.
Source: SLEEP
DOI: 10.1093/sleep/zsaa218
Authors: Josef Fritz, Andrew J K Phillips, Larissa C Hunt, Akram Imam, Kathryn J Reid, Krista M Perreira, Yasmin Mossavar-Rahmani, Martha L Daviglus, Daniela Sotres-Alvarez, Phyllis C Zee, Sanjay R Patel, Céline Vetter
Institutions: University of Colorado Boulder, Monash University, Northwestern University, University of North Carolina at Chapel Hill, Albert Einstein College of Medicine, University of Illinois Chicago, University of Pittsburgh
Language: English
Field: Psychology
Open Access status: green
Funders: Office of Dietary Supplements, University of Miami, University of North Carolina, Northwestern University, San Diego State University, National Institutes of Health, Albert Einstein College of Medicine, Yeshiva University, National Institute on Aging, National Heart, Lung, and Blood Institute, National Institute on Deafness and Other Communication Disorders, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Neurological Disorders and Stroke, National Institute of Dental and Craniofacial Research, National Center on Minority Health and Health Disparities, National Institute on Minority Health and Health Disparities, Eunice Kennedy Shriver National Institute of Child Health and Human Development
Awards: G1064233440, G1120543537, Hispanic Community Health Study, G1666450717, G1972514365, G2135211244, G2215135821, HISPANIC COMMUNITY HEALTH STUDY - FIELD CENTER, G2495941498, G2528054427, G2970637568, Hispanic Community Health Study, Hispanic Community Health Study, G5365244667, HISPANIC COMMUNITY HEALTH STUDY - COORDINATING CENTER, G543802643, G6075306088, Carolina Population Center, G820454163, G8343337543
OpenAlex ID: W3094056622
FWCI: 4.818
Cites: 69
Cited by: 47
Related to: 10