Work

Modular Synthesis of Streptogramin Antibiotics

Year: 2020

Type: article

Abstract: Streptogramins are antibiotics produced by several species of Streptomyces bacteria that are used in both human and veterinary medicine. Group A streptogramins comprise 23-membered macrocyclic polyketide/nonribosomal peptide hybrids for which several innovative fully synthetic routes have been developed. Herein we describe in detail our scalable routes to natural Group A streptogramins and we compare these routes to other reported syntheses.

Source: Synlett

DOI: 10.1055/a-1293-9655

Authors: Qi Li, Ian B. Seiple

Institution: University of California, San Francisco

Language: English

Topic: Microbial Natural Products and Biosynthesis

Subfield: Pharmacology

Field: Medicine

Domain: Health Sciences

Open Access status: green

Funders: David and Lucile Packard Foundation, National Institute of General Medical Sciences

Award: Platforms for the Synthesis of Bacterial Protein Synthesis Inhibitors