Polyphenol Intake and Gastric Cancer Risk: Findings from the Stomach Cancer Pooling Project (StoP)
Year: 2020
Type: article
Abstract: Phenolic compounds may exert a favorable effect on the risk of several cancer types, including gastric cancer (GC). However, selected polyphenol classes have not been adequately investigated in relation to GC. The aim of this study is to evaluate the association between the intake of polyphenols in relation to GC risk. We used data from the Stomach cancer Pooling (StoP) Project, including 10 studies from six countries (3471 GC cases and 8344 controls). We carried out an individual participant data pooled analysis using a two-stage approach. The summary odds ratios (ORs) of GC for each compound, and the corresponding 95% confidence intervals (95% CI), were computed by pooling study specific ORs obtained through multivariate logistic regression, using random effect models. Inverse associations with GC emerged for total polyphenols (OR = 0.67, 95% CI = 0.54-0.81, for the highest versus lowest quartile of intake), total flavonoids (OR = 0.73, 95% CI = 0.55-0.90), anthocyanidins (OR = 0.74, 95% CI = 0.56-0.92), flavanols (OR = 0.77, 95% CI = 0.66-0.88), flavanones (OR = 0.57, 95%CI = 0.44-0.69), total phenolic acids (OR = 0.75, 95%CI = 0.55-0.94), and hydroxybenzoic acids (OR = 0.73, 95%CI = 0.57-0.89). Results were consistent across strata of age, sex, social class, and smoking habit. Suggestive inverse associations were also found for flavonols (OR = 0.76, 95%CI = 0.51-1.01) and hydroxycinnamic acids (OR = 0.82, 95%CI = 0.58-1.06). Further investigations from longitudinal data are needed to confirm this association.
Source: Cancers
Authors: Facundo Vitelli-Storelli, Marta Rossi, Claudio Pelucchi, Matteo Rota, Domenico Palli, Monica Ferraroni, Nuno Lunet, Samantha Morais, Lizbeth López-Carrillo, David Georgievich Zaridze, Dmitry Maximovich, María Rubín García, Gemma Castaño-Vinyals, Nuria Aragonés, Manuela Garcia de la Hera, Raúl Ulises Hernández-Ramírez, Eva Negri, Rossella Bonzi, Mary H. Ward, Areti Lagiou, Pagona Lagiou, Malaquías López-Cervantes, Paolo Boffetta, M. Constanza Camargo, Maria Paula Curado, Zuo-Feng Zhang, Jesus Vioque, Carlo La Vecchia, Vicente Martín Sánchez
Institutions: Universidad de León, University of Milan, University of Brescia, Universidade do Porto, Institute of Public Health, University of Porto, Instituto Nacional de Salud Pública, Russian Cancer Research Center NN Blokhin, Universitat Pompeu Fabra, Municipal Institute for Medical Research, Barcelona Institute for Global Health, Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública, Hospital del Mar Research Institute, Instituto de Investigación Sanitaria y Biomédica de Alicante (ISABIAL), Yale University, Division of Cancer Epidemiology and Genetics, University of West Attica, Harvard University, National and Kapodistrian University of Athens, Universidad Nacional Autónoma de México, Stony Brook University, University of Bologna, AC Camargo Hospital, University of California, Los Angeles, UCLA Jonsson Comprehensive Cancer Center
Language: English
Topic: Nutritional Studies and Diet
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,324
Funders: Kræftens Bekæmpelse, Associazione Italiana per la Ricerca sul Cancro, Universidad de Huelva, Universidad de Cantabria, Universidad de Oviedo, Universidade do Porto, Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana, Universidad de León, National Institutes of Health, Fundação para a Ciência e a Tecnologia, Instituto de Salud Carlos III, National Center for Advancing Translational Sciences
Awards: G1516346500, G1763632427, Unidade de Investigação em Epidemiologia - Instituto de Saúde Pública da Universidade do Porto, G3840324753, G5224927334, G5452987910, G5454278309, G6573712672, Complicações neuro-oncológicas do cancro da próstata: estudo longitudinal do declínio cognitivo, Yale Clinical and Translational Science Award
OpenAlex ID: W3094424583