Work

Exploring role of 5hmC as potential marker of chemoresistance

Year: 2020

Type: editorial

Abstract: Chemoresistance remains to be a common and significant hurdle with all chemotherapies. Tumors gain resistance by acquiring additional mutations. Some of the chemoresistance mechanisms are known and can be tackled. However, the majority of chemoresistance mechanisms are unknown. Our recent findings shed light on one such unknown mechanism. We identified a novel role for 5-hydroxymethycytosine (5hmC), an epigenetic mark on the DNA, in maintaining the integrity of stalled replication forks and its impact on genomic stability and chemoresistance.

Source: Molecular & Cellular Oncology

DOI: 10.1080/23723556.2020.1827904

Authors: Suhas S. Kharat, Shyam K. Sharan

Institutions: National Institutes of Health, National Cancer Institute, Center for Cancer Research

Language: English

Topic: Epigenetics and DNA Methylation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $1,590