Novel prognostic scoring system for autologous hematopoietic cell transplantation in multiple myeloma
Year: 2020
Type: article
Study design: Observational Study
Abstract: We studied 2,528 patients with upfront autologous haematopoietic cell transplantation (AHCT) for multiple myeloma (MM) from 2008-2017 to develop a prognostic model to predict outcomes. High-risk cytogenetics included t(4;14), t(14;16), t(14;20), del13q on karyotype, del17p, +1q or 1pdel. A Cox model identified factors prognostic of progression/relapse in a training subset (n = 1,246). A weighted score using these factors was assigned to a validation cohort (n = 774). Presence of high-risk cytogenetics [hazard ratio, (HR) 1·68 (1·3-2·17)] and pre-AHCT bone marrow plasma cells (BMPCs) ≥10% [1·68 (1·33-2·12)] were assigned 4 points each; albumin at diagnosis <3·5 g/dl [1·31 (1·07-1·61)] 2; standard risk cytogenetics 1, and no cytogenetics abnormality, BMPCs <10% at AHCT and albumin ≥3·5 g/dl at diagnosis 0 points each. A three-category system with low risk (0-3), intermediate risk (4-8) and high risk (9-10) showed 3-year progression-free survival in the low vs. intermediate vs. high risk of 58% (95% CI: 52-63) vs. 49% (95% CI: 43-56) vs. 31% (95% CI: 12-51), P < 0.001 respectively, and 3-year OS in low vs. intermediate vs. high risk of 88% (95% CI: 84-91) vs. 81% (95% CI: 76-86) vs. 64% (95% CI: 39-80); P < 0·001. Our prognostic scoring system can identify MM patients at risk for early relapse after AHCT.
Source: British Journal of Haematology
DOI: 10.1111/bjh.16987
Authors: Binod Dhakal, Anita D’Souza, Natalie Callander, Saurabh Chhabra, Raphael Fraser, Omar Davila, Kenneth Anderson, Amer Assal, Sherif M. Badawy, Jesus Berdeja, Jan Cerny, Raymond Comenzo, Rajshekhar Chakraborty, Robert Peter Gale, Rammurti Kamble, Mohamed A. Kharfan‐Dabaja, Maxwell Krem, Siddhartha Ganguly, Murali Janakiram, Ankit Kansagra, Reinhold Munker, Hemant Murthy, Sagar Patel, Shaji Kumar, Nina Shah, Muzaffar Qazilbash, Parameswaran Hari
Institutions: Medical College of Wisconsin, University of Wisconsin–Madison, University of Wisconsin Carbone Cancer Center, Dana-Farber Cancer Institute, Columbia University Irving Medical Center, Columbia University, Northwestern University, Lurie Children's Hospital, Sarah Cannon, University of Massachusetts Chan Medical School, Tufts Medical Center, Cleveland Clinic, Imperial College London, Baylor College of Medicine, Mayo Clinic, Mayo Clinic in Florida, University of Louisville Hospital, The University of Kansas Health System, Montefiore Medical Center, The University of Texas Southwestern Medical Center, University of Kentucky, Markey Cancer Center, University of Utah, University of California, San Francisco, The University of Texas MD Anderson Cancer Center
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: Cost Effectiveness Analysis of Stem Cell Transplant in Older MDS Patients, Identifying Predictors of Poor Health-Related Quality-of-life among Pediatric Hematopoietic Stem Cell Donors, G1664930879, G192962028, G2564302013, G3158753476, G345720138, G3699198379, G460283006, G5186918478, G6079157135, G746619137, G772836402, Molecular and Cellular Mechanisms of Chronic Myelomonocytic Leukemia (CMML), Immuno and Epigenetics of Hematopoietic Cell Transplantation, A Data Resource for Blood and Marrow Transplants and Adoptive Cellular Therapy Research, NK cells, their receptors and cancer therapy, Blood and Marrow Transplant Clinical Trials Network DCC- The Medical College of Wisconsin, Inc., Hematopoietic Stem Cell And Cord Blood Transplantation
OpenAlex ID: W3094613554