Work

Genetic Events and Signaling Mechanisms Underlying Schwann Cell Fate in Development and Cancer

Year: 2020

Type: review

Abstract: In this review, we describe Schwann cell development from embryonic neural crest cells to terminally differentiated myelinated and nonmyelinated mature Schwann cells. We focus on the genetic drivers and signaling mechanisms mediating decisions to proliferate versus differentiate during Schwann cell development, highlighting pathways that overlap with Schwann cell development and are dysregulated in tumorigenesis. We conclude by considering how our knowledge of the events underlying Schwann cell development and mouse models of schwannoma, neurofibroma, and malignant peripheral nerve sheath tumor can inform novel therapeutic strategies for patients with cancers derived from Schwann cell lineages.

Source: Neurosurgery

DOI: 10.1093/neuros/nyaa455

Authors: Harish N Vasudevan, Calixto-Hope G Lucas, Javier E Villanueva-Meyer, Philip V Theodosopoulos, David R Raleigh

Institutions: University of California, San Francisco, University of San Francisco

Language: English

Topic: Neurofibromatosis and Schwannoma Cases

Subfield: Clinical Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Children's Tumor Foundation, National Institutes of Health, National Cancer Institute