Work

Cannabis and the Gut–Brain Axis Communication in HIV Infection

Year: 2020

Type: article

Abstract: People living with HIV infection (PWH) disclose that cannabis is an effective strategy for alleviating symptoms associated with HIV disease. However, some medical providers feel ill-informed to engage in evidence-based conversations. HIV leads to alterations in the gut microbiome, gut-brain axis signaling, and chronic inflammation. The endocannabinoid system regulates homeostasis of multiple organ systems. When deficient, dysregulation of the gut-brain axis can result in chronic inflammation and neuroinflammation. Cannabis along with the naturally occurring endocannabinoids has antioxidant and anti-inflammatory properties that can support healing and restoration as an adjunctive therapy. The purpose of this literature review is to report the physiologic mechanisms that occur in the pathology of HIV and discuss potential benefits of cannabinoids in supporting health and reducing the negative effects of comorbidities in PWH.

Source: Cannabis and Cannabinoid Research

DOI: 10.1089/can.2020.0037

Authors: Natalie L. Wilson, Scott N. Peterson, Ronald J. Ellis

Institutions: University of California, San Francisco, Sanford Burnham Prebys Medical Discovery Institute, University of California San Diego

Language: English

Topic: Cannabis and Cannabinoid Research

Subfield: Pharmacology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green