Work

Reproductive Complications in Childhood Cancer Survivors

Year: 2020

Type: review

Abstract: Gonadal dysfunction and infertility after cancer treatment are major concerns for childhood cancer survivors and their parents. Uncertainty about fertility or being diagnosed with infertility has a negative impact on quality of survival. In this article, determinants of gonadal damage are reviewed and consequences for fertility and pregnancies are discussed. Recommendations for screening and treatment of gonadal function are provided. These should enable timely treatment of gonadal insufficiency aiming to improve linear growth, pubertal development, and sexual functioning. Options for fertility preservation are discussed.

Source: Pediatric Clinics of North America

DOI: 10.1016/j.pcl.2020.08.003

Authors: Hanneke M. van Santen, Marianne D. van de Wetering, Annelies M.E. Bos, Marry M. vd Heuvel-Eibrink, Helena J. van der Pal, William Hamish Wallace

Institutions: University Medical Center Utrecht, Princess Máxima Center, Wilhelmina Children's Hospital, Royal Hospital for Sick Children

Language: English

Topic: Reproductive Biology and Fertility

Subfield: Reproductive Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,430