Work

A New Generation of “Magic Bullets” for Molecular Targeting of Cancer

Year: 2020

Type: article

Abstract: A two-step molecular targeting approach involving a self-assembling and disassembling (SADA) bispecific antibody platform and DOTA-radioconjugates allows tumor-specific delivery of diagnostic and therapeutic payloads. Low immunogenicity and the modular nature of SADA allow its optimization to safely and repeatedly deliver a variety of payloads to tumors expressing diverse tumor-specific antigens. See related article by Santich et al., p. 532

Source: Clinical Cancer Research

DOI: 10.1158/1078-0432.ccr-20-3690

Authors: Jacek Capala, Charles A. Kunos

Institutions: National Institutes of Health, National Cancer Institute

Language: English

Topic: Radiopharmaceutical Chemistry and Applications

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funder: National Cancer Institute