Year: 2012
Type: dissertation
Abstract: Bisphosphonates are well known class of organophosphorus compounds having biological and industrial applications and their development is ongoing.Among other prospectives of bisphosphonates the partial bisphosphonate esters present an interest for use in biological systems with their increased lipophilicity.Current research is aiming to make one more step in chemistry of partial bisphosphonate esters with transport-optimised side chain in order to approach the calcium imaging utility.The literature overview is aimed to show the dialectics of studies in this field and to highlight the major approaches to the synthesis of bisphosphonates.The experimental part is dedicated to the problems of synthesis and purification of individual compounds.The synthesis and isolation of new compounds are described and possible reaction mechanisms are discussed.Abbreviations Ala -beta-alanine ATP-adenosine triphosphate DIPEA -diisopropylethylamine DMEBP -P, P'-dimethyl ethenylidene-1,1-bisphosphonate DMF -dimethyl formamide FPPS -farnesyl pyrophosphate synthase GGPPS -geranylgeranyl pyrophosphate synthase LDA -lithium diisopropylamide Me-ala -beta-alanine methyl ester NBP -nitrogen containing bisphosphonates NNBP -non-nitrogen containing bisphosphonates OPG -osteoprotogerine OPGL -osteoprotogerine ligand PFA -paraformaldehyde RANK -receptor activator of nuclear factor κB THF -tetrahydrofurane TMEBP -tetramethyl ethenylidene-1,1-bisphosphonate TRANCE -tumor necrosis factor related activation induced cytokine
Author: Alexander А. Kondrasenko
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W3095884427