Work

T cell factor 1: A master regulator of the T cell response in disease

Year: 2020

Type: article

Abstract: Recent advances have redefined a role for T cell factor 1 (TCF1) that goes beyond T cell development and T memory formation and encompasses new functions in the regulation of T cell biology. Here, we discuss the multifaceted and context-dependent role of TCF1 in peripheral T cells, particularly during disease-induced inflammatory states such as autoimmunity, cancer, and chronic infections. Understanding how TCF1 fine-tunes peripheral T cell biology holds the potential to tailor improved immune-targeted therapies.

Source: Science Immunology

DOI: 10.1126/sciimmunol.abb9726

Authors: Giulia Escobar, Davide Mangani, Ana C. Anderson

Institutions: Brigham and Women's Hospital, Harvard University, Mass General Brigham

Language: English

Topic: T-cell and B-cell Immunology

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung, National Cancer Institute, National Institute of Allergy and Infectious Diseases