Analysis of structural brain asymmetries in attention‐deficit/hyperactivity disorder in 39 datasets
Year: 2021
Type: article
Abstract: OBJECTIVE: Some studies have suggested alterations of structural brain asymmetry in attention-deficit/hyperactivity disorder (ADHD), but findings have been contradictory and based on small samples. Here, we performed the largest ever analysis of brain left-right asymmetry in ADHD, using 39 datasets of the ENIGMA consortium. METHODS: We analyzed asymmetry of subcortical and cerebral cortical structures in up to 1,933 people with ADHD and 1,829 unaffected controls. Asymmetry Indexes (AIs) were calculated per participant for each bilaterally paired measure, and linear mixed effects modeling was applied separately in children, adolescents, adults, and the total sample, to test exhaustively for potential associations of ADHD with structural brain asymmetries. RESULTS: There was no evidence for altered caudate nucleus asymmetry in ADHD, in contrast to prior literature. In children, there was less rightward asymmetry of the total hemispheric surface area compared to controls (t = 2.1, p = .04). Lower rightward asymmetry of medial orbitofrontal cortex surface area in ADHD (t = 2.7, p = .01) was similar to a recent finding for autism spectrum disorder. There were also some differences in cortical thickness asymmetry across age groups. In adults with ADHD, globus pallidus asymmetry was altered compared to those without ADHD. However, all effects were small (Cohen's d from -0.18 to 0.18) and would not survive study-wide correction for multiple testing. CONCLUSION: Prior studies of altered structural brain asymmetry in ADHD were likely underpowered to detect the small effects reported here. Altered structural asymmetry is unlikely to provide a useful biomarker for ADHD, but may provide neurobiological insights into the trait.
DOI: 10.1111/jcpp.13396
Authors: Merel C. Postema, Martine Hoogman, Sara Ambrosino, Philip Asherson, Tobias Banaschewski, Cibele E. Bandeira, Alexandr Baranov, Claiton H.D. Bau, Sarah Baumeister, Ramona Baur‐Streubel, Mark A. Bellgrove, Joseph Biederman, Janita Bralten, Daniel Brandeis, Silvia Brem, Jan K. Buitelaar, Geraldo F. Busatto, Francisco X. Castellanos, Mara Cercignani, Tiffany M. Chaim‐Avancini, Kaylita C. Chantiluke, Anastasia Christakou, David Coghill, Annette Conzelmann, Ana I. Cubillo, Renata B. Cupertino, Patrick de Zeeuw, Alysa E. Doyle, Sarah Durston, Eric A. Earl, Jeffery N. Epstein, Thomas Ethofer, Damien A. Fair, Andreas J. Fallgatter, Stephen V. Faraone, Thomas Frodl, Matt C. Gabel, Tinatin Gogberashvili, Eugenio H. Grevet, Jan Haavik, Neil A. Harrison, Catharina A. Hartman, Dirk J. Heslenfeld, Pieter J. Hoekstra, Sarah Hohmann, Marie F. Høvik, Terry L. Jernigan, Bernd Kardatzki, Georgii Karkashadze, Clare Kelly, Gregor Kohls, Kerstin Konrad, Jonna Kuntsi, Luisa Lazaro, Sara Lera‐Miguel, Klaus‐Peter Lesch, Mario R. Louza, Astri J. Lundervold, Charles B Malpas, Paulo Mattos, Hazel McCarthy, Leyla Namazova‐Baranova, Rosa Nicolau, Joel T. Nigg, Stephanie E. Novotny, Eileen Oberwelland Weiss, Ruth L. O'Gorman Tuura, Jaap Oosterlaan, Bob Oranje, Yannis Paloyelis, Paul Pauli, Felipe A. Picon, Kerstin J. Plessen, J. Antoni Ramos‐Quiroga, Andreas Reif, Liesbeth Reneman, Pedro G.P. Rosa, Katya Rubia, Anouk Schrantee, Lizanne J.S. Schweren, Jochen Seitz, Philip Shaw, Tim J. Silk, Norbert Skokauskas, Juan C. Soliva Vila, Michael C. Stevens, Gustavo Sudre, Leanne Tamm, Fernanda Tovar‐Moll, Theo G.M. van Erp, Alasdair Vance, Oscar Vilarroya, Yolanda Vives‐Gilabert, Georg G. von Polier, Susanne Walitza, Yuliya N. Yoncheva, Marcus V. Zanetti, Georg C. Ziegler, David C. Glahn, Neda Jahanshad, Sarah E. Medland, ENIGMA ADHD Working Group, Paul M. Thompson, Simon E. Fisher, Barbara Franke, Clyde Francks
Institutions: Max Planck Institute for Psycholinguistics, Radboud University Nijmegen, Radboud University Medical Center, Donders Institute for Brain, Cognition and Behaviour, Utrecht University, University Medical Center Utrecht, King's College London, Heidelberg University, Central Institute of Mental Health, Medizinische Fakultät Mannheim, Universidade Federal do Rio Grande do Sul, Hospital de Clínicas de Porto Alegre, Russian Academy of Sciences, Central Clinical Hospital and Polyclinic, University of Würzburg, Monash University, Harvard University, Massachusetts General Hospital, University of Zurich, ETH Zurich, University Hospital Zurich, Psychiatrische Universitätsklinik Zürich, Universidade de São Paulo, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Nathan Kline Institute for Psychiatric Research, New York University, Brighton and Sussex Medical School, University of Reading, The University of Melbourne, Murdoch Children's Research Institute, Universitätsklinikum Tübingen, PFH Private University of Applied Sciences, Oregon Health & Science University, Cincinnati Children's Hospital Medical Center, University of Cincinnati, University of Tübingen, SUNY Upstate Medical University, Trinity College Dublin, Otto-von-Guericke-Universität Magdeburg, Scientific Center of Children's Health, Haukeland University Hospital, University of Bergen, Sussex Partnership NHS Foundation Trust, University Medical Center Groningen, University of Groningen, Vrije Universiteit Amsterdam, University of California San Diego, Universitätsklinikum Aachen, RWTH Aachen University, Forschungszentrum Jülich, Jülich Aachen Research Alliance, Centro de Investigación Biomédica en Red de Salud Mental, Consorci Institut D'Investigacions Biomediques August Pi I Sunyer, Universitat de Barcelona, Hospital Clínic de Barcelona, Sechenov University, Maastricht University, The Royal Melbourne Hospital, Universidade Federal do Rio de Janeiro, D’Or Institute for Research and Education, St. James's Hospital, Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation, Hartford Hospital, University Children's Hospital Zurich, Emma Kinderziekenhuis, Amsterdam University Medical Centers, Amsterdam Reproduction Development, University of Amsterdam, Mental Health Services, Centre Hospitalier Universitaire Vaudois, Universitat Autònoma de Barcelona, Vall d'Hebron Institut de Recerca, Vall d'Hebron Hospital Universitari, University Hospital Frankfurt, Amsterdam UMC Location University of Amsterdam, National Human Genome Research Institute, National Institute of Mental Health, Deakin University, Norwegian University of Science and Technology, Yale University, University of California, Irvine, Hospital Del Mar, Municipal Institute for Medical Research, Hospital del Mar Research Institute, Universitat Politècnica de València, NYU Langone Health, Hospital Sírio-Libanês, Boston Children's Hospital, University of Southern California, QIMR Berghofer Medical Research Institute
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,800
Funders: Ford Foundation, Autism Speaks, American Academy of Child and Adolescent Psychiatry, Oregon Health and Science University, Ministry of Science and Technology, Washington University in St. Louis, Ministry of Health, Health Research Board, Instituto D'Or de Pesquisa e Ensino, Deutsche Forschungsgemeinschaft, Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung, ZonMw, Universiteit van Amsterdam, Erasmus Universiteit Rotterdam, Vrije Universiteit Amsterdam, Generalitat de Catalunya, Erasmus Medisch Centrum, Nederlandse Organisatie voor Wetenschappelijk Onderzoek, Accare, Max-Planck-Gesellschaft, Universitair Medisch Centrum Groningen, Radboud Universitair Medisch Centrum, Universität Zürich, Collier Charitable Fund, National Institutes of Health, Oregon Clinical and Translational Research Institute, Intellectual and Developmental Disabilities Research Center, National Health and Medical Research Council, National Institute of Mental Health, National Institute on Drug Abuse, National Human Genome Research Institute, National Institute of Neurological Disorders and Stroke, National Institute of Biomedical Imaging and Bioengineering, National Center for Advancing Translational Sciences, Eunice Kennedy Shriver National Institute of Child Health and Human Development
Awards: G1521682985, Translational Developmental Neuroscience of Autism, G1916274067, G2237947903, Neuroimaging of cognitive flexibility and action monitoring in paediatric obsessive-compulsive disorder (OCD) and attention deficit-hyperactivity disorder (ADHD), Brain trajectories in ADHD, G3093765122, G3382646295, G3415342020, G3431959885, G346726432, G347462301, G3608658220, Advancing our understanding of Psychiatric Disorders through Imaging and Genetics, G3750586882, Discovery Science of Human Brain Function Across the Lifespan, G4076811867, G4770524819, Analysis of an ADHD Whole Genome Association Scan, G5094325759, G534927285, Functional and Structural Connectivity in Adult Attention Deficit Hyperactivity D, Adolescent Changes in Brain and Behavior in Boys and Girls with ADHD, G5547472187, International Multi-Center ADHD Genetics Project, Resting states of the brain and state dependent information processing in health and disease, G606092624, ENIGMA Center for Worldwide Medicine, Imaging & Genomics, G624558668, 2/2 - Anomalous Motor System Physiology in ADHD: Biomarker Validation and Modeling Domains of Function, Longitudinal Discovery of Brain Developmental Trajectories, Motor Skill Learning in Autism, Longitudinal Imaging Study of ADHD Brain Development, Using Statistical Genetics to Elucidate the Effects of Disease Associated Genetic Variants within the Human Brain, G827289500, G9000112492, G9000198788, Boston Children's Hospital/HMS Intellectual and Developmental Disabilities Research Center, Oregon Clinical and Translational Research Institute, 6/21 ABCD-USA CONSORTIUM: RESEARCH PROJECT SITE AT OHSU, G940556611
OpenAlex ID: W3130499904