DDX56 Binds to Chikungunya Virus RNA To Control Infection
Year: 2020
Type: article
Abstract: Arthropod-borne viruses are diverse pathogens and include the emerging virus chikungunya virus, which is associated with human disease. Through genetic screening, we found that the conserved RNA binding protein DDX56 is antiviral against chikungunya virus in insects and humans. DDX56 relocalizes from the nucleus to the cytoplasm, where it binds to a stem-loop in the viral genome and destabilizes incoming genomes. Thus, DDX56 is an evolutionarily conserved antiviral factor that controls alphavirus infection.
Source: mBio
Institution: University of Pennsylvania
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,900
Awards: The role of pattern recognition and autophagy in innate anti-bunyaviral immunity, G1586078693, Elucidating the functional roles of long noncoding RNAs in Chikungunya virus infection, Training Program in Cell and Molecular Biology, G2700640572, G2869901831, G618623535, Defining the functional interface between the ER and flaviviruses, G865181799, G91632081
OpenAlex ID: W3096227767