Work

Histone demethylase LSD1 is critical for endochondral ossification during bone fracture healing

Year: 2020

Type: article

Abstract: expression level. The increased retinoic acid signaling in LSD1-deficient mice suppressed SOX9 expression and impeded the cartilaginous callus formation during fracture repair. The discovery that LSD1 can regulate endochondral ossification during fracture healing will benefit the understanding of bone regeneration and have implications for regenerative medicine.

Source: Science Advances

DOI: 10.1126/sciadv.aaz1410

Authors: Jun Sun, Heng Feng, Wenhui Xing, Yujiao Han, Jinlong Suo, Alisha R. Yallowitz, Niandong Qian, Yujiang Shi, Matthew B. Greenblatt, Weiguo Zou

Institutions: Chinese Academy of Sciences, Center for Excellence in Molecular Cell Science, University of Chinese Academy of Sciences, Weill Cornell Medicine, State Key Laboratory of Cell Biology, Shanghai Jiao Tong University, Ruijin Hospital, Boston Children's Hospital, Harvard University

Language: English

Topic: Bone Metabolism and Diseases

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $4,500

Funders: National Natural Science Foundation of China, National Institute of Arthritis and Musculoskeletal and Skin Diseases

Awards: G1069696150, G4558027284, G7577319136

OpenAlex ID: W3096336038

FWCI: 1.126

Cites: 45

Cited by: 36

Related to: 10