Terahertz (THz) studies of real pharmaceutical tablets compressed with indomethacin as an active pharmaceutical ingredient (API)
Year: 2016
Type: dissertation
Abstract: Terahertz (THz) studies involving real pharmaceutical tablets have been undertaken.A total of 110 tablets which has been compressed with indomethacin as an active pharmaceutical ingredient (API) was used in this work.These 110 real tablets were grouped into four sets.In each sample set, at least one of the following tablet parameters were varied; porosity, f, API mass fraction, k and height, H.A home built THz spectrometer from the University of Cambridge was used to measure the THz time delay pulse for each of the samples.From the THz time delay pulse, the effective refractive index, n eff was calculated for each sample set.The linear correlation between the effective refractive index and the porosity for pharmaceutical tablets without API as reported by Bawuah et al. has been confirmed for these sets of real pharmaceutical tablets as well.Furthermore, a linear correlation was also found to exist between the effective refractive index and the API mass fraction.The variation of the height had no effect on the effective refractive index.However, the height variation presented ways of checking the porosity variations when the height of the pharmaceutical tablet falls within an acceptable range.Of the two tablet parameters; porosity and API mass fraction, the porosity had a greater effect on the effective refractive index than the API mass fraction. Samuel TweneboahTerahertz studies of real pharmaceutical tablets compressed with indomethacin as an active pharmaceutical ingredient (API), 53 pages
Author: Samuel Nana Adekson Tweneboah
Language: English
Subfield: Electrical and Electronic Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W3096494027