Work

The Non-Alcoholic Steatohepatitis and Cardiovascular Disease Intersection, an Important Consideration in Drug Development

Year: 2020

Type: article

Abstract: Background: Cardio-Ankle Vascular Index (CAVI) has become an acceptable tool for evaluating the arterial stiffness and predicting higher cardiovascular (CV) risk in asymptomatic individuals.The higher the CAVI level, the higher the CV risk.CAVI level is affected by many variables including age, diabetes and BMI.We intend to evaluate the impact of diabetes on CAVI in men and women to see if this can be used as a reliable indicator for initiating preventive measures in diabetics.Methods: We enrolled 285 individuals between 18 to 80 years of age with body mass index (BMI) between 18 and 39.9 (kg/m2) who were referred for CCTA at The Lundquist institute at Harbor-UCLA medical center.After obtaining informed consent, CAVI was performed using vascular screening system (VaSera) VS-1500 AU (FUKUDA Denshi, Tokyo, Japan).Multiple linear regression was used to assess clinical predictors of CAVI level.SAS software (version 9.4) was used to carry out all statistical analyses with p<0.05 considered significant.Results: The average age of the study participants was 55.8 years Æ 13.5 with mean BMI of 28.7 Æ5.4.Diabetes, Age and BMI were associated with elevated CAVI, p<0.0001 for all.Both subgroups of men and women with diabetes had significantly higher mean CAVI scores than those without DM.Males and females with diabetes had similar scores, underscoring the loss of cardio-protection that occurs when females develop type 2 DM.Females without diabetes had significantly lower CAVI than their non-diabetic male counterparts (p¼ 0.021), Table 1.Conclusions: Diabetes has a strong impact on CAVI level in men and women.Higher CAVI in diabetic men and women can be used in the clinical practice as a reliable tool to identify the asymptomatic diabetic people at higher CV risk who will benefit from more aggressive therapies and interventions to decrease this risk.

Source: American Journal of Preventive Cardiology

DOI: 10.1016/j.ajpc.2020.100048

Authors: Seth Baum, Barton Isaac, Rebecca Taub, Stephen A. Harrison

Institutions: Florida Atlantic University, Madrigal Pharmaceuticals (United States), University of Oxford

Language: English

Topic: Cardiovascular Health and Disease Prevention

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,900