Work

Assessment of individual and standardized glucagon kinetics in healthy humans

Year: 2020

Type: article

Abstract: State-of-the-art measurement of insulin secretion in humans is accomplished by deconvolution of peripheral C-peptide concentrations using population-derived parameters of C-peptide kinetics. In contrast, knowledge of the kinetic parameters of glucagon in humans is lacking so that measurement of glucagon secretion to date is largely qualitative. This series of experiments enabled measurement of glucagon kinetics in 51 subjects, and subsequently, stepwise linear regression was used to correlate these parameters with anthropometric characteristics. This enabled the development of a population-based model using anthropometric characteristics to predict the volume of distribution and the rate of clearance. This is a necessary first step in the development of a model to quantitate of glucagon secretion and action (and its contribution to glucose tolerance) in large populations.

Source: American Journal of Physiology-Endocrinology and Metabolism

DOI: 10.1152/ajpendo.00488.2020

Authors: Marcello C. Laurenti, Adrian Vella, Jon D. Adams, Daniel J. Schembri Wismayer, Aoife M. Egan, Chiara Dalla Man

Institutions: Mayo Clinic, University of Padua

Language: English

Topic: Pancreatic function and diabetes

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases