Analysis of distinct SF3B1 hotspot mutations in relation to clinical phenotypes and response to therapy in myeloid neoplasia

Year: 2020

Type: article

Abstract: Here we investigate single codon SF3B1 mutations (K700E, K666, H662) to identify whether discrete amino acid substitutions may influence clinical phenotypes, survival and response to treatments in ...

Source: Leukemia & lymphoma/Leukemia and lymphoma

DOI: 10.1080/10428194.2020.1839647

Institutions: Cleveland Clinic, Cleveland Clinic Research, Universitat Autònoma de Barcelona, Josep Carreras Leukaemia Research Institute, Institut Català d'Oncologia, University of Arizona, University of Arizona Cancer Center

Language: English

Topic: Acute Myeloid Leukemia Research

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Japan Society for the Promotion of Science, National Heart, Lung, and Blood Institute, National Cancer Institute

Awards: Development of lysosome targeted therapeutics, Therapeutic Implications of Molecular Defects in Bone Marrow Failure, Novel Spliceosomal Defects in Myelodysplastic Syndromes, Clarifying clonal architecture diversity of leukemia dervied from myelodysplastic syndromes

OpenAlex ID: W3097144642