Year: 2020
Type: article
Study design: Observational Study
Abstract: OBJECTIVE: To test the hypothesis that leisure activity participation is associated with lower dementia risk, we examined the association between participation in leisure activities and incident dementia in a large longitudinal study with average 18-year follow-up. METHODS: We used data from 8,280 participants of the Whitehall II prospective cohort study. A 13-item scale assessed leisure activity participation in 1997-1999, 2002-2004, and 2007-2009, and incidence of dementia (n cases = 360, mean age at diagnosis 76.2 years, incidence rate 2.4 per 1,000 person-years) was ascertained from 3 comprehensive national registers with follow-up until March 2017. Primary analyses were based on complete cases (n = 6,050, n cases = 247) and sensitivity analyses used multiple imputation for missing data. RESULTS: Participation in leisure activities at mean age 55.8 (1997-1999 assessment), with 18.0-year follow-up, was not associated with dementia (hazard ratio [HR] 0.92 [95% confidence interval 0.79-1.06]), but those with higher participation at mean age 65.7 (2007-2009 assessment) were less likely to develop dementia with 8.3-year follow-up (HR 0.82 [0.69-0.98]). No specific type of leisure activity was consistently associated with dementia risk. Decline in participation between 1997-1999 and 2007-2009 was associated with subsequent dementia risk. CONCLUSION: Our findings suggest that participation in leisure activities declines in the preclinical phase of dementia; there was no robust evidence for a protective association between leisure activity participation and dementia. Future research should investigate the sociobehavioral, cognitive, and neurobiological drivers of decline in leisure activity participation to determine potential approaches to improving social participation of those developing dementia.
Source: Neurology
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Awards: Role of mid- and late-life risk factors in social inequalities in Alzheimer's Disease and Related Dementias, The Whitehall II study: A Core Resource for Ageing Research, Vascular risk and functional decline in old age: from discovery to translation, Social disengagement as a marker of cognitive decline, Prevention of dementia by targeting risk factors, Education, socioeconomic status and Aging: transitions from multimorbidity to functional limitations and mortality, Psychosocial work environment and healthy ageing, Vascular risk and functional decline in old age (renewal)
OpenAlex ID: W3097469476