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Novel Lipid Species for Detecting and Predicting Atrial Fibrillation in Patients With Type 2 Diabetes

Year: 2020
Type: article
Abstract: The incidence of atrial fibrillation (AF) is higher in patients with diabetes. The goal of this study was to assess if the addition of plasma lipids to traditional risk factors could improve the ability to detect and predict future AF in patients with type 2 diabetes. Logistic regression models were used to identify lipids associated with AF or future AF from plasma lipids (n = 316) measured from participants in the ADVANCE trial (n = 3,772). To gain mechanistic insight, follow-up lipid analysis was undertaken in a mouse model that has an insulin-resistant heart and is susceptible to AF. Sphingolipids, cholesteryl esters, and phospholipids were associated with AF prevalence, whereas two monosialodihexosylganglioside (GM3) ganglioside species were associated with future AF. For AF detection and prediction, addition of six and three lipids, respectively, to a base model (n = 12 conventional risk factors) increased the C-statistics (detection: from 0.661 to 0.725; prediction: from 0.674 to 0.715) and categorical net reclassification indices. The GM3(d18:1/24:1) level was lower in patients in whom AF developed, improved the C-statistic for the prediction of future AF, and was lower in the plasma of the mouse model susceptible to AF. This study demonstrates that plasma lipids have the potential to improve the detection and prediction of AF in patients with diabetes.
Source: Diabetes
DOI: 10.2337/db20-0653
Authors: Yow Keat Tham, Kaushala S. Jayawardana, Zahir H. Alshehry, Corey Giles, Kevin Huynh, Adam Alexander T. Smith, Jenny Y.Y. Ooi, Sophia Zoungas, Graham S. Hillis, John Chalmers, Peter J. Meikle, Julie R. McMullen
Institutions: Baker Heart and Diabetes Institute, Monash University, The University of Melbourne, UNSW Sydney, The George Institute for Global Health, The University of Western Australia, Royal Perth Hospital, La Trobe University
Language: English
Field: Medicine
Open Access status: bronze
Awards: Targeting lipids to treat heart failure, Lipidomics of Obesity, Type 2 Diabetes and Cardiovascular Disease, Effects of intensive blood pressure lowering and blood glucose control in diabetes., Providing the evidence to prevent and treat heart attack and stroke., Identifying and developing novel therapeutic approaches for heart disease, Targeting a new regulator of cardiac pathology to protect the heart from cardiac dysfunction and arrhythmia
OpenAlex ID: W3097554023
FWCI: 1.265
Cites: 25
Cited by: 14
Related to: 10