Year: 2020
Type: review
Abstract: Life expectancy has steadily increased over the past century, as has the occurrence of age-related diseases, most notably myocardial diseases. Aging is often accompanied by increased low-grade chronic inflammation, accumulation of terminally differentiated T-cells poised with proinflammatory phenotypes, and clonal hematopoiesis. These systemic alterations have been consistently shown to impact myocardial physiology, individual susceptibility to heart diseases and long-term heart disease prognosis. In recent years, progress has been made in understanding the interindividual (cross-sectional) and intraindividual (longitudinal) variability in the global immunosenescence profile, and novel immune-aging metric-based scoring systems bearing potential to predict cardiovascular events have emerged. We herein suggest that monitoring the patients’ individual immunosenescence trajectories, in addition to the classic cardiological work-up, could provide valuable diagnostic/prognostic information. Similarly, we propose that basic research in cardio-immunology could attain a deeper mechanistic understanding of age-related diseases and a more meaningful translational impact if the ‘aging context’ was embraced more systematically.
Source: Current Opinion in Physiology
Institution: Universitätsklinikum Würzburg
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,500
Awards: ERA-CVD, Verbund AIR-MI: Die Rolle der Adaptiven Immunantwort nach Myokardinfarkt (AIR-MI), Untersuchung des Zusammenhangs von Immunoseneszenz und Heilung nach Myokardinfarkt, G622427043, Adaptive immune responses in the wounded heart: novel diagnostic and therapeutic opportunities, G6932736780
OpenAlex ID: W3097646291