Antipsychotic Treatment-resistance in Schizophrenia: Subtypes, Treatment Response, and Long-term Outcome
Year: 2019
Type: dissertation
Study design: Observational Study
Abstract: Background: Treatment-Resistant Schizophrenia (TRS) is a sub-group of schizophrenia (20%-30%). Some patients present with no initial response to non-clozapine compounds (TRS from the outset), while others develop it over time. Methods: We explore short-term response trajectories and long-term outcome (symptom severity, functioning, cognition, subjective well-being) among 120 clozapine-treated patients with standardized algorithm. Differences between TRS sub-types are identified. Results: In total, 78/120 patients present with TRS from the outset while 42/120 develop TRS, achieving remission rates of 65.4% and 85.7%, respectively. Significant time-illness group interactions (p
Source: TSpace (University of Toronto)
Author: Parnian Pardis
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W3097785663