Improved Markers of Cholestatic Liver Injury in Patients With Primary Biliary Cholangitis Treated With Obeticholic Acid and Bezafibrate
Year: 2020
Type: article
Abstract: A decrease or normalization of alkaline phosphatase (ALP) and bilirubin levels in patients treated for primary biliary cholangitis (PBC) predicts a better survival. Obeticholic acid (OCA) is the approved second-line therapy if ursodeoxycholic acid (UCDA) fails, but its use may worsen pruritus. Adding bezafibrate to UCDA improved biochemical markers of cholestatic liver injury and decreased pruritus severity. Because normalization of ALP and bilirubin was only achieved in a minority of patients in these studies, we explored whether bezafibrate (off-label drug) could improve the effect of OCA (licensed drug) on cholestasis.
Source: Hepatology
DOI: 10.1002/hep.31613
Institution: KU Leuven
Language: English
Topic: Liver Diseases and Immunity
Subfield: Hepatology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W3097914939