Work

A phenomenological approach to the simulation of metabolism and proliferation dynamics of large tumour cell populations

Year: 2005

Type: article

Abstract: A major goal of modern computational biology is to simulate the collective behaviour of large cell populations starting from the intricate web of molecular interactions occurring at the microscopic level. In this paper we describe a simplified model of cell metabolism, growth and proliferation, suitable for inclusion in a multicell simulator, now under development (Chignola R and Milotti E 2004 Physica A 338 261-6). Nutrients regulate the proliferation dynamics of tumour cells which adapt their behaviour to respond to changes in the biochemical composition of the environment. This modelling of nutrient metabolism and cell cycle at a mesoscopic scale level leads to a continuous flow of information between the two disparate spatiotemporal scales of molecular and cellular dynamics that can be simulated with modern computers and tested experimentally.

Source: Physical Biology

DOI: 10.1088/1478-3967/2/1/002

Authors: Roberto Chignola, Edoardo Milotti

Institutions: University of Verona, Istituto Nazionale di Fisica Nucleare, Sezione di Trieste, University of Udine, Istituto Nazionale di Fisica Nucleare, Gruppo Collegato di Udine

Language: English

Topic: Mathematical Biology Tumor Growth

Subfield: Modeling and Simulation

Field: Mathematics

Domain: Physical Sciences

Open Access status: bronze

Funders: Istituto Nazionale di Fisica Nucleare, Nuclear Physics

OpenAlex ID: W2034696745

FWCI: 2.702

Cites: 41

Cited by: 28

Related to: 10