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The Funnel: a Screening Technique for Identifying Optimal Two-Drug Combination Chemotherapy Regimens

Year: 2020

Type: article

Abstract: The Mycobacterium tuberculosis drug discovery effort has generated a substantial number of new/repurposed drugs for therapy for this pathogen. The arrival of these drugs is welcome, but another layer of difficulty has emerged.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.02172-20

Authors: G. L. Drusano, Sarah Kim, Mohammed Almoslem, Stephan Schmidt, D. Z. D’Argenio, Jenny Myrick, Brandon Duncanson, Jocelyn Nole, David Brown, C. A. Peloquin, Michael Neely, Walter Yamada, Arnold Louie

Institutions: University of Florida, University of Ha'il, University of Southern California, Children's Hospital Los Angeles

Language: English

Topic: Tuberculosis Research and Epidemiology

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institute of Allergy and Infectious Diseases, National Institute of Biomedical Imaging and Bioengineering

Awards: Rapid Identification of Optimal Combination Regimens for Pseudomonas aeruginosa, Biomedical Simulations Resource (BMSR), Optimizing Combination Therapy to Accelerate Clinical Cure of Tuberculosis

OpenAlex ID: W3099039161

FWCI: 0.328

Cites: 25

Cited by: 13

Related to: 10