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UCHL3 promotes proliferation of colorectal cancer cells by regulating SOX12 via AKT/mTOR signaling pathway.

Year: 2020

Type: article

Abstract: OBJECTIVE: The dysregulation of deubiquitinating enzymes is important in the development of many cancers, including colorectal cancer (CRC). However, the precise function and potential mode of action of the deubiquitinating enzyme UCHL3 in CRC progression are poorly elucidated. METHODS: . RESULTS: also showed enhanced tumor growth due to UCHL3 overexpression. In addition, UCHL3 was found regulates SOX12 expression in CRC cells. PI3K/AKT/mTOR pathway is required for UCHL3-mediated SOX12 expression. Mechanically, UCHL3 regulates SOX12 via AKT/mTOR signaling pathway and facilitated tumor progression. CONCLUSION: UCHL3 plays an oncogenic role through the AKT/mTOR/SOX12 axis and can be considered as a potential target for therapy and CRC prognostic biomarker.

Source: PubMed Central

Authors: Jiangning Li, Yang Zheng, Xiaofeng Li, Xue Dong, Weiyan Chen, Zhongying Guan, Chong Zhang

Institutions: Shenyang First People's Hospital, Liaoning Cancer Hospital & Institute, Shenyang Center for Disease Control and Prevention, Affiliated Hospital of Liaoning University of Traditional Chinese Medicine

Language: English

Topic: Ubiquitin and proteasome pathways

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W3099835752

FWCI: 0.8

Cites: 43

Cited by: 30

Related to: 10