Year: 2020
Type: review
Abstract: The mammalian globin gene clusters provide a paradigm for studying the relationship between genome structure and function. As blood stem cells undergo lineage specification and differentiation to form red blood cells, the chromatin structure and expression of the α-globin cluster change. The gradual activation of the α-globin genes in well-defined cell populations has enabled investigation of the structural and functional roles of its enhancers, promoters and boundary elements. Recent studies of gene regulatory processes involving these elements at the mouse α-globin cluster have brought new insights into the general principles underlying the three-dimensional structure of the genome and its relationship to gene expression throughout time.
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $4,350
Awards: Developing an initiative in stem cell editing for human genetic diseases., Global Study of Thalassaemia, The regulation of globin gene expression during haematopoiesis, Exploring mechanisms of enhancer action in erythropoiesis, Switching mammalian genes on and off during development, lineage specification, and differentiation, and its impact on human genetic disease, Exploring mechanisms of enhancer action in erythropoiesis
OpenAlex ID: W3100505464