Year: 2020
Type: article
Abstract: Cancer stem cells (CSCs) are a crucial therapeutic target because of their role in resistance to chemo- and radiation therapy, metastasis, and tumor recurrence. Differentiation therapy presents a potential strategy for "defanging" CSCs. To date, only a limited number of small-molecule and nanomaterial-based differentiating agents have been identified. We report here the integrated use of nanoparticle engineering and hypothesis-free sensing to identify nanoparticles capable of efficient differentiation of CSCs into non-CSC phenotypes. Using this strategy, we identified a nanoparticle that induces CSC differentiation by increasing intracellular reactive oxygen species levels. Importantly, this unreported phenotype is more susceptible to drug treatment than either CSCs or non-CSCs, demonstrating a potentially powerful strategy for anticancer therapeutics.
Source: ACS Nano
Language: English
Topic: Cancer Cells and Metastasis
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: G2011973597, G2342700005, G2546072107, Mechanisms of Carcinoma Initiation and Differentiation, G54542315, G5617892821, G564936820, Targeting of Bio-orthogonal Chemotherapeutic Nanozymes to Tumor-Associated Macrophages, Nanosensor-Based Phenotypic Screening for Precision Therapy of Cancer Stem Cells, Integrin splicing and cancer stem cell fate, G7455104372, G9000025506, G9000034341, G9000169891
OpenAlex ID: W3101099396