Work

Sorafenib increases tumor treating fields-induced cell death in glioblastoma by inhibiting STAT3.

Year: 2020

Type: article

Abstract: silencing can also be accomplished by RNA interference and can increase the TTFields-sensitizing effect of sorafenib. If the effects are reversed and gene regulating STAT3 is expressed more, it annihilates the effects of treatment. Moreover, sorafenib plus TTFields significantly inhibited xenograft tumor growth and combinatorial treatment reduced STAT3 expression more effectively in vivo. These in vitro and in vivo results indicate that sorafenib tends to sensitize GBM cells to TTFields-induced apoptosis by inhibiting STAT3.

Source: PubMed

Authors: Jeong-Yub Kim, Yunhui Jo, Hoon-Kyu Oh, Eun Ho Kim

Institutions: Korea Institute of Radiological and Medical Sciences, Korea University, Daegu Catholic University, Daegu Catholic University Medical Center

Language: English

Topic: Glioma Diagnosis and Treatment

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W3101232593

FWCI: 1.285

Cites: 34

Cited by: 22

Related to: 10