Year: 2020
Type: article
Study design: Observational Study
Abstract: Object ve: Understanding the genetic nature of injuries in athletes may be conceived as an important step in the prevention and rehabilitation process of the injuries.The aim of this study is to analyze the rs1800012 genotype and allele distribution of the collagen type I alpha 1 gene (COL1A1), which is effective in non-contact injuries of long distance and short distance runners.Mater al and Methods: A total of 94 participants, including 19 long distance runners, 25 short distance runners and 50 sedentary individuals were enrolled in the study.Genomic DNA was isolated from oral epithelial cells using the Invitrogen DNA isolation kit (Invitrogen, USA) according to the manufacturers' protocol.Genotyping was performed with real-time PCR.Results: There were no statistically significant differences between long distance-short distance (p=0.870),short distance-sedentary individuals (p=0.510) and long distance-sedentary individuals (p=0.201) group variables in terms of genotype.Similarly, when the same groups were compared in terms of allelic distribution (respective p values 0.680, 0.337 and 0.201), there were no statistically significant differences. Conclus on:In the study, it was found that GG genotype and G allele were higher for rs1800012 polymorphism than the other genotypes.Therefore, both athletes and sedentary individuals are considered to be less at risk of non-impact injury predisposition.
DOI: 10.47447/tjsm.0469
Language: Turkish
Subfield: Genetics
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W3102579175