Biochemical studies on the protective effect of honey against doxorubicin-induced toxicity in BALB/C mice.
Year: 2020
Type: article
Abstract: OBJECTIVE: Doxorubicin-mediated chemotherapy has been linked in cancer patients with acute toxic manifestations. This study aimed to assess the protective effect of natural honey against doxorubicin-induced toxicity in mice. METHODS: Forty male BALB/C mice were divided randomly and equally into four groups of ten mice. Group I was on a normal diet and served as the control. Group II received only honey to investigate its antitoxic effects (oral administration at 10 g/kg for 10 days). Group III was injected with a single dose of doxorubicin (10 mg/kg i.p.). Group IV received both doxorubicin and honey. On day 11, blood was taken from the various groups of mice and the quantitative and qualitative changes were observed in the white blood cells. The levels of hepatic, renal, and cardiac toxicity biomarkers including aspartate aminotransaminase (AST), alanine aminotransaminase (ALT), blood nitrogen urea (BUN), serum creatinine, lactate dehydrogenase (LDH), and creatinine kinase (CK) were also assessed. RESULTS: 0.05). CONCLUSION: The findings suggest that the consumption of natural honey can alleviate doxorubicin-induced toxicity in cancer patients.
Source: PubMed Central
Author: Fahad A Alhumaydhi
Institution: Qassim University
Language: English
Subfield: Toxicology
Domain: Life Sciences
Open Access status: green
Funder: Qassim University
OpenAlex ID: W3103251443