Work

HLA autoimmune risk alleles restrict the hypervariable region of T cell receptors

Year: 2022

Type: article

Study design: Observational Study

Source: Nature Genetics

DOI: 10.1038/s41588-022-01032-z

Authors: Kazuyoshi Ishigaki, Kaitlyn A. Lagattuta, Yang Luo, Eddie A. James, Jane H. Buckner, Soumya Raychaudhuri

Institutions: Broad Institute, Brigham and Women's Hospital, Harvard University, RIKEN Center for Integrative Medical Sciences, Benaroya Research Institute, Manchester Academic Health Science Centre, University of Manchester

Language: English

Topic: Genetic Associations and Epidemiology

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: U.S. Department of Health and Human Services, Uehara Memorial Foundation, Kennedy Trust for Rheumatology Research, National Institutes of Health, Japan Society for the Promotion of Science, National Human Genome Research Institute, National Institute of General Medical Sciences, National Institute of Allergy and Infectious Diseases, National Institute of Arthritis and Musculoskeletal and Skin Diseases

Awards: G1418759429, RA-SLE Molecular Deconstruction Leadership Center, G1962389589, Identification of transcription factor controlling autoimmunity risk allele's pathogenic function, G3281679040, Medical Scientist Training Program, Metabolic factors that control the spectrum of human tuberculosis, G3728880812, Leveraging functional data to predict disease risk in multi-ethnic populations, Functionally specialized components of disease heritability in ENCODE data, Defining the influence of RA genetic susceptibility factors on T cell antigen specificity and functional state, Establishment of individualized anti-cytokine therapy based on functional analysis of risk polymorphisms for autoimmune diseases, G8780883752, G9000041795, G9000268936, Predicting the impact of genetic variants, genes and pathways on human Disease, G932915660

OpenAlex ID: W4220721882

FWCI: 12.47

Cites: 50

Cited by: 104

Related to: 10