Work

Preoperative Platelet to Albumin Ratio Predicts Outcome of Patients with Non-Small-Cell Lung Cancer

Year: 2020

Type: article

Abstract: OBJECTIVE: The purpose of this study was to evaluate the predictive power of the platelet to albumin ratio (PAR) on survival outcomes of patients with non-small-cell lung cancer (NSCLC). PATIENTS AND METHODS: In all, 198 patients with NSCLC were recruited. The X-tile software was performed to identify the optimal cutoff values for PAR, platelet to lymphocyte ratio (PLR), and neutrophil to lymphocyte ratio (NLR). The Kaplan-Meier method, univariate and multivariate analyses Cox regression were used to analyze the prognostic factors for overall survival (OS). RESULTS: (P <0.001), PLR > 147.7 (P <0.001), and NLR >3.9 (P = 0.007) were associated with poor OS. Multivariate analyses found that PAR was an independent predictor in NSCLC patients (hazard ratio [HR]: 4.604, 95% confidence interval [CI]: 2.557-8.290, P <0.001). CONCLUSION: Preoperative PAR is a useful and potential prognostic biomarker in NSCLC patients who have received primary resection.

Source: Annals of Thoracic and Cardiovascular Surgery

DOI: 10.5761/atcs.oa.20-00090

Authors: Manman Guo, Ting Sun, Zhuochen Zhao, Liang Ming

Institution: First Affiliated Hospital of Zhengzhou University

Language: English

Topic: Inflammatory Biomarkers in Disease Prognosis

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $753