Work

Antioxidant Activity of Telmisartan–Cu(II) Nanoparticles Connected 2‐Pyrimidinamine and Their Evaluation of Cytotoxicity Activities

Year: 2020

Type: article

Abstract: Copper nanoparticles (Cu‐Nps) are one of the promising materials for the advancement of nanoscience and technology. In this work, we synthesized telmisartan copper nanoparticles and 2‐pyrimidinamines via Biginelli reaction using telmisartan copper nanoparticles (Cu‐Nps) as a reusable catalyst. The synthesis of 2‐pyrimidinamine derivatives (1a‐c) was achieved in water and under solvent‐free condition (Green chemistry approach). Synthesis of 2‐pyrimidinamine with telmisartan copper nanoparticle (Cu‐Nps–Pyr) unexpected product was also isolated from synthesis of 2‐pyrimidinamine preparation. Antioxidant and cytotoxic activities were carried out both in 2‐pyrimidinamine (1a‐1c) and 2‐pyrimidinamine with telmisartan copper nanoparticles (Cu‐Nps–Pyr). The synthesized 2‐pyrimidinamine derivatives (1a‐c) were characterized from FT‐IR, 1H and 13C NMR spectroscopy, mass and elemental analyses. The synthesized telmisartan copper nanoparticles (Cu‐Nps) were characterized from UV spectroscopy, XRD, SEM, EDX, AFM (atomic force microscopy), profile, waviness, and roughness analyses. Antioxidant activity was screened based on ABTS⋅+ radical scavenging and linoleic acid peroxidation performance. Cu‐Nps–Pyr‐1b showed substantial antioxidant (97.2%) activity against ABTS⋅+ assay and 91.2% activity against AAPH assays compared with Trolox. Cytotoxicity was evaluated using HepG2, HeLa, and MCF‐7 cell lines, the Cu‐Nps–Pyr‐1a is high in toxicities (GI50 = 0.01 μm) against the HeLa cancel cell line compared with doxorubicin. The developed copper NPs with 2‐pyrimidinamine (Cu‐Nps–Pyr) could provide promising advances as antioxidant activities; this nanocomposition could be considered an anticancer treatment in future investigations.

Source: BioMed Research International

DOI: 10.1155/2020/8872479

Authors: Radhakrishnan Surendrakumar, Akbar Idhayadhulla, Saud Alarifi, Nazeer Anis Ahamed, Chidambaram Sathish Kumar

Institutions: Bharathidasan University, King Saud University

Language: English

Topic: Multicomponent Synthesis of Heterocycles

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $2,680