Work

SARS-CoV-2 and interferon blockade

Year: 2020

Type: review

Abstract: The response to viral infection generally includes an activation of the adaptive immune response to produce cytotoxic T cells and neutralizing antibodies. We propose that SARS-CoV-2 activates the innate immune system through the renin-angiotensin and kallikrein-bradykinin pathways, blocks interferon production and reduces an effective adaptive immune response. This model has therapeutic implications.

Source: Molecular Medicine

DOI: 10.1186/s10020-020-00231-w

Authors: Betty Diamond, Bruce T. Volpe, Sonya VanPatten, Yousef Al Abed

Institution: Feinstein Institute for Medical Research

Language: English

Topic: SARS-CoV-2 and COVID-19 Research

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,790