Work

TDP-43 induces EMT and promotes hepatocellular carcinoma metastasis via activating Wnt/β-catenin signaling pathway.

Year: 2020

Type: article

Abstract: mRNA and regulate the level of GSK3β protein translation. Taken together, our findings suggest that TDP-43 may activate the Wnt/β-catenin pathway by targeting the inhibition of GSK3β protein translation, thus inducing the proliferation and metastasis of HCC cells, which supports its potential value as a therapeutic target for the treatment of metastatic HCC.

Source: PubMed

Authors: Feixia Guo, Hongwei Wang, Min Jiang, Qingguo Yang, Qi Xiang, Hongyin Zhou, Xuemei Hu, Kaixuan Hao, Jie Yang, Hongwen Cao, Zhifa Shen

Institutions: Wenzhou Medical University, First Affiliated Hospital of Wenzhou Medical University

Language: English

Topic: Wnt/β-catenin signaling in development and cancer

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W3105659513

FWCI: 1.142

Cites: 50

Cited by: 28

Related to: 10