From a melt of rings to chromosome territories: the role of topological constraints in genome folding
Year: 2014
Type: review
Abstract: We review pro and contra of the hypothesis that generic polymer properties of topological constraints are behind many aspects of chromatin folding in eukaryotic cells. For that purpose, we review, first, recent theoretical and computational findings in polymer physics related to concentrated, topologically simple (unknotted and unlinked) chains or a system of chains. Second, we review recent experimental discoveries related to genome folding. Understanding in these fields is far from complete, but we show how looking at them in parallel sheds new light on both.
Source: Reports on Progress in Physics
Authors: Jonathan D Halverson, Jan Smrek, Kurt Kremer, Alexander Y Grosberg
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W2016696510