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Circulating B Cells, Plasma Cells, and Treg Associate with ANCA Levels in ANCA-associated Vasculitis

Year: 2020

Type: article

Abstract: Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV) are a group of debilitating autoimmune diseases characterized by uncontrolled inflammation and endothelial injury that often associates with pauci-immune necrotizing and crescentic glomerulonephritis. Despite the improved therapeutic options, both mortality and development of end-stage kidney disease remain high among AAV patients.1 More importantly, complications associated with treatments continue to pose as major risk factors for infection, cardiovascular disease, and malignancy.

Source: Kidney International Reports

DOI: 10.1016/j.ekir.2020.11.016