Work

Transcriptional and signalling regulation of skin epithelial stem cells in homeostasis, wounds and cancer

Year: 2020

Type: review

Abstract: The epidermis and skin appendages are maintained by their resident epithelial stem cells, which undergo long-term self-renewal and multilineage differentiation. Upon injury, stem cells are activated to mediate re-epithelialization and restore tissue function. During this process, they often mount lineage plasticity and expand their fates in response to damage signals. Stem cell function is tightly controlled by transcription machineries and signalling transductions, many of which derail in degenerative, inflammatory and malignant dermatologic diseases. Here, by describing both well-characterized and newly emerged pathways, we discuss the transcriptional and signalling mechanisms governing skin epithelial homeostasis, wound repair and squamous cancer. Throughout, we highlight common themes underscoring epithelial stem cell plasticity and tissue-level crosstalk in the context of skin physiology and pathology.

Source: Experimental Dermatology

DOI: 10.1111/exd.14247

Authors: Yinglu Guan, Youn Joo Yang, Priyadharsini Nagarajan, Yejing Ge

Institution: The University of Texas MD Anderson Cancer Center

Language: English

Topic: Hair Growth and Disorders

Subfield: Urology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Cancer Prevention and Research Institute of Texas, National Institute of Arthritis and Musculoskeletal and Skin Diseases