Work

Production of Radiohalogens: Bromine and Astatine for Imaging and Therapy

Year: 2020

Type: report

Abstract: Over the course of this two year grant, we have developed and optimized new methods for the production of clinical quality 76Br, 77Br, and 80mBr at the University of Wisconsin. This includes the synthesis of a novel isotopically enriched cobalt-selenium intermetallic compound, its fabrication into robust cyclotron targets, and the chemical isolation of the resulting bromine radionuclide. Compared with the previous state-of-the-art, these methods demonstrate a six-times larger 76Br and three-times larger 77Br production capacity for a 3-hour cyclotron irradiation. Additionally, the cyclotron targets are exceptionally robust to this process, allowing for their reuse for dozens of radiobromine productions.

DOI: 10.2172/1682261

Authors: Univ. of Wisconsin, Madison, WI (United States), Paul Ellison, USDOE Office of Science (SC), Engineering & Technology. Office of Isotope R&D and Production, Jonathan Engle, Aeli Olson, Todd Barnhart, Robert Nickles, Sabrina Hoffman, Dhanabalan Murali, Onofre DeJesus, Bryan Bednarz

Institution: University of Wisconsin–Madison

Language: English

Topic: Radiopharmaceutical Chemistry and Applications

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

Open Access status: gold

Funder: U.S. Department of Energy

Award: PRODUCTION OF RADIOHALOGENS: BROMINE AND ASTATINE FOR IMAGING AND THERAPY

OpenAlex ID: W3107085255

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