Year: 2020
Type: review
Study designs: Systematic Review, Meta-Analysis
Abstract: BACKGROUND/AIMS: In this systematic review and meta-analysis, we aimed to clarify the effect of obesity on the occurrence of and mortality from primary liver cancer. METHODS: This study was conducted using a systematic literature search of MEDLINE, EMBASE, and the Cochrane Library until November 2018 using the primary keywords "obesity," "overweight," "body mass index (BMI)," "body weight," "liver," "cancer," "hepatocellular carcinoma," "liver cancer," "risk," and "mortality." Studies assessing the relationship between BMI and occurrence of or mortality from primary liver cancer in prospective cohorts and those reporting hazard ratios (HRs) or data that allow HR estimation were included. RESULTS: A total of 28 prospective cohort studies with 8,135,906 subjects were included in the final analysis. These included 22 studies with 6,059,561 subjects for cancer occurrence and seven studies with 2,077,425 subjects for cancerrelated mortality. In the meta-analysis, an increase in BMI was associated with the occurrence of primary liver cancer (HR, 1.69; 95% confidence interval, 1.50-1.90, I2=56%). A BMI-dependent increase in the risk of occurrence of primary liver cancer was reported. HRs were 1.36 (95% CI, 1.02-1.81), 1.77 (95% CI, 1.56-2.01), and 3.08 (95% CI, 1.21-7.86) for BMI >25 kg/m2, >30 kg/m2, and >35 kg/m2, respectively. Furthermore, increased BMI resulted in enhanced liver cancer-related mortality (HR, 1.61; 95% CI, 1.14-2.27, I2=80%). CONCLUSION: High BMI increases liver cancer mortality and occurrence of primary liver cancer. Obesity is an independent risk factor for the occurrence of and mortality from primary liver cancer.
Institutions: Kangbuk Samsung Hospital, Sungkyunkwan University, Yonsei University, Gangnam Severance Hospital, Catholic Kwandong University International St. Mary's Hospital, Catholic Kwandong University, Samsung Medical Center, Hanyang University Guri Hospital, The Catholic University of Korea Seoul St. Mary's Hospital
Language: English
Topic: Cancer Risks and Factors
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $32
Funders: Korea University Guro Hospital, Seoul National University, Soonchunhyang University, University of Ulsan, Yonsei University, Korea University, Sungkyunkwan University, Catholic University of Korea, Seoul National University Hospital, Samsung, College of Medicine, Seoul National University, College of Medicine, Catholic University of Korea
OpenAlex ID: W3107494356