Work

NF-κB and Extrinsic Cell Death Pathways – Entwined Do-or-Die Decisions for T cells

Year: 2020

Type: review

Abstract: NF-κB signaling is required at multiple stages of T cell development and function. The NF-κB pathway integrates signals from many receptors and involves diverse adapters and kinases. Recent advances demonstrate that kinases controlling NF-κB activation, such as the IKK complex, serve dual independent functions because they also control cell death checkpoints. Survival functions previously attributed to NF-κB are in fact mediated by these upstream kinases by novel mechanisms. This new understanding has led to a refined view of how NF-κB and cell death signaling are interlinked and how they regulate cell fate. We discuss how NF-κB activation and control of cell death signaling by common upstream triggers cooperate to regulate different aspects of T cell development and function.

Source: Trends in Immunology

DOI: 10.1016/j.it.2020.10.013

Authors: Sam Blanchett, Ines Boal-Carvalho, Scott Layzell, Benedict Seddon

Institutions: The Royal Free Hospital, University College London

Language: English

Topic: NF-κB Signaling Pathways

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $4,000

Funder: Medical Research Council